111年第二次藥物治療學解析71

71.承上題,下列何者最適合用於預防胃出血?

A.ranitidine

B. sucralfate

C.esomeprazole

D. bismuth

答: C

 

解答:參照Applied Therapeutics: The Clinical Use of Drugs (11 Edition)

Chapter 23 Upper Gastrointestinal Disorders

Drug regimens used to treat and prevent NSAID-induced ulcers are identified in Table 23-1. Patients with NSAID-induced ulcers should be tested to determine their H. pylori status. If the patient is H. pylori negative, the NSAID should be discontinued and treatment should be initiated with antiulcer medications. The duration of treatment should be extended if the NSAID is continued. Prophylactic cotherapy with a PPI or misoprostol or switching to an NSAID with greater COX-2 selectivity is recommended for patients at risk of exhibiting ulcer-related upper GI complications.

優先選擇PPI、misoprostol 或是greater COX-2 selectivity NSAID,故答案選C (PPI)。

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