52.病人有bipolar disorder，下列何者最易造成其情緒轉換（快速由鬱期轉為躁期或輕躁症）？
A.carbamazepine
B.quetiapine
C.lorazepam
D.venlafaxine
答案: D
解答：
Although far from certain, it is likely that different antidepressant classes confer different vulnerability to switching (Peet 1994; Gijsman et al. 2004; Tondo et al. 2010; Vasquez et al. 2013). Tricyclics are generally considered to have the highest switch rate while selective serotonin reuptake inhibitors (SSRIs) and bupropion confer the lowest risk. Serotonin/norepinephrine reuptake inhibitors (SNRIs) (at least, venlafaxine) are associated with higher risks than SSRIs and bupropion (Vieta et al. 2002; Post et al. 2006). Whether this increased risk is shared with other SNRIs such as duloxetine and desmethylvenlafaxine is unknown. Switch rates with monoamine oxidase (MAO) inhibitors are generally considered to be less than with tricyclics although data supporting this are not available (Himmelhoch et al. 1991).
參考文獻：https://journalbipolardisorders.springeropen.com/articles/10.1186/s40345-018-0133-9