111年第二次藥物治療學解析33

33.下列何者最不適合用於治療懷孕婦女之發炎性腸道疾病?

A.cyclosporine

B.dexamethasone

C.mesalamine without dibutyl phthalate

D.sulfasalazine + folate

答案B

解答:

根據 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095568/

  FDA category Comments during pregnancy
cyclosporine C Low risk
dexamethasone C Probably low risk, avoid during first trimester (potential risk of oral clefts)
mesalamine B Low risk: Limited data for olsalazine; if using sulfasalazine, folic acid supplementation is mandatory
sulfasalazine B

故答案選(B)

(註)目前文獻資料對於cyclosporine及dexamethasone用於治療懷孕婦女之發炎性腸道疾病有不同之解讀和建議使用方式,故仍須依患者實際情形考量用藥選擇。

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