33.下列何者最不適合用於治療懷孕婦女之發炎性腸道疾病?
A.cyclosporine
B.dexamethasone
C.mesalamine without dibutyl phthalate
D.sulfasalazine + folate
答案B
解答:
根據 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095568/
FDA category | Comments during pregnancy | |
cyclosporine | C | Low risk |
dexamethasone | C | Probably low risk, avoid during first trimester (potential risk of oral clefts) |
mesalamine | B | Low risk: Limited data for olsalazine; if using sulfasalazine, folic acid supplementation is mandatory |
sulfasalazine | B |
故答案選(B)
(註)目前文獻資料對於cyclosporine及dexamethasone用於治療懷孕婦女之發炎性腸道疾病有不同之解讀和建議使用方式,故仍須依患者實際情形考量用藥選擇。