11.25 kg之10歲兒童，醫師欲開立sodium valproate oral solution 20 mg/kg/day BID，共28天，目前藥局之藥品為200 mg/mL, 40 mL/bottle，應如何建議處方？
A.1.25 mL PO BID，共1 bottle
B.1.25 mL PO BID，共2 bottles
C.2.5 mL PO QD，共2 bottles
D.2.5 mL PO BID，共4 bottles
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答案:B
解析
總發藥量：總需求劑量/藥品規格
= [20 (mg/kg/day) x 25 (kg) x 28 (day)] / [200 (mg/mL) x 40 (mL/bot)]
= [14000 (mg) / 8000 (mg/bot)]
= 1.75 bot，應給病人2 bottles
單次使用體積：單次劑量(20mg/kg/day BID → 10 mg/kg)/藥品規格
= [10 (mg/kg) x 25 (kg)] / [ 200 (mg/mL)]
= [250 (mg)] / [200 (mg/mL)]
= 1.25 mL
用法用量為1.25 mL PO BID，共2 bottles